Hydrogel-Elastomer Composite Biomaterials – 3. Effects of Gelatin Molecular Weight and Type on the Preparation and Physical Properties of Interpenetrating Polymer Networks

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Authors
  1. Peng, H.
  2. Martineau, L.
  3. Shek, P.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
To optimize the preparation of a gelatin-HydroThane™ Interpenetrating Polymer Network (IPN) and obtain optimum physical properties for its use as a wound dressing, we studied IPN films prepared with two types of gelatin having different molecular weights. The effects of the gelatin molecular weight and type on the IPN film’s structure, morphology, swelling and mechanical properties were determined. While FTIR did not reveal any noticeable differences between the IPNs prepared using different gelatin, light microscopy showed a lesser phase separation of the film prepared with a high-molecular-weight type A gelatin. Furthermore, these films displayed slightly less swelling, higher strength and lower strain, compared to the IPNs prepared with either low-molecular-weight type A or type B gelatin. The IPN prepared with type B gelatin showed higher swelling in serum-containing medium than those prepared with type A gelatin, because of its ionic charges under the condition. Increases in viscosity were observed with increasing molecular weight, type A being more viscous than type B gelatin despite having a lower bloom number. The viscosity of the high-molecular-weight gelatin was in the same magnitude as that of HydroThane™, which might lead to less phase separation. A better understanding of the effects of alterations in the gelatin molecular weight and type on the formation and properties of the gelatin-HydroThane™ IPN should facilitate the development of promising composit

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Keywords
Hydrogel;Elastomer;Gelatin Type;Molecular weight;Interpenetrating Polymer Network
Report Number
DRDC-TORONTO-SL-2006-244 — Scientific Literature
Date of publication
01 Jul 2007
Number of Pages
11
Reprinted from
Journal of Materials Science: Materials in Medicine, no 19, 2008, p 997-1007
DSTKIM No
CA030786
CANDIS No
529440
Format(s):
Electronic Document(PDF)

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