Hydrogel-Elastomer Composite Biomaterials: 4. Experimental Optimization of Hydrogel-Elastomer Composite Fibers for use as a Wound Dressing

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Authors
  1. Peng, H.T.
  2. Martineau, L.
  3. Hung, A.H.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
To develop a novel 3-D wound dressing based on a hydrogel-elastomer Interpenetrating Polymer Network (IPN) and an open-mesh architecture; IPN fibers were produced by a wet spinning method and optimized by the experiments designed in two steps. First, a factorial experiment was conducted to identify key parameters for making the IPN fibers. We observed that gelatin wt% played a major role in controlling fiber yield, swelling, strength and stability, followed by acetone vol% in the coagulation solution, type of gelatin, pre- and post-UV irradiation time. Second, the identified key factors were examined by changing one variable each time to obtain a condition that provided a combination of good swelling, mechanical properties and stability. The concentrations of gelatin/HydroThane™ solutions had important effects on the fiber formation and properties due to the changes in their solution viscosities. The effects of pre-UV irradiation were also ascribed to its impact on the solution viscosity and became negligible at a higher concentration. The composition of the coagulation bath influenced the fiber swelling and wet stress. These results, together with our previous studies, suggest that our biomaterial would provide a combination of mechanical and swelling properties suitable for wound dressing applications.

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Keywords
Hydrogel;Elastomer;Interpenetrating polymer network;Polymer fiber
Report Number
DRDC-TORONTO-SL-2007-047 — Scientific Literature
Date of publication
01 May 2008
Number of Pages
11
Reprinted from
Journal of Materials Science: Materials in Medicine, vol 19, 2008, p 1803-1813
DSTKIM No
CA030859
CANDIS No
529516
Format(s):
Electronic Document(PDF)

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