BIOCHEMICAL STUDIES OF LIPOSOMES USED AS CARRIERS FOR CHEMICAL PROPHYLAXIS

Authors
  1. Barber, R.F.
  2. Stanacev, N.Z.
  3. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Clinical Biochemistry
Abstract
Topically applied liposomes containing acetylcholinesterase have been shown to provide a significant level of protection against ocular exposure to a model organophosphate. Exposure of this liposomal preparation to tear fluid results in the release of entrapped agents and consequently it was necessary to determine the nature of acetylcholinesterase interaction with the carrier vehicle. Unilamellar liposomes prepared from DMPC in the presence and absence of acetylcholinesterase, as obtained from a commercial source or following purification by column chromatography, were examined by ESR for lipid/protein interactions.
Date of publication
15 Sep 1987
Number of Pages
69
DSTKIM No
87-04293
CANDIS No
53067
Format(s):
Hardcopy;Originator's fiche received by DSIS

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