Inhibition of the replication of Venezuelan equine encephalitis virus by retinotic acid-inducible gene-I

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Authors
  1. Wu, J.Q.H.
  2. Huang, D.
  3. Chan-Wong, E.
  4. Chau, D.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Retinoic acid-inducible gene I (RIG-I) is a cytoplasmic protein that recognizes viral RNA molecules and subsequently elicits antiviral innate responses. This report describes a pilot study on the feasibility of developing RIG-I into a novel antiviral drug against alphaviruses. It was found that RIG-I, when expressed in cells from a plasmid vector, inhibits the replication of Venezuelan equine encephalitis virus (VEEV), which was used as a model pathogen of the alphaviruses. It appears that the inhibition is related to RIG-I’s ability to induce the production of interferon alpha. The result from this study helps the further evaluation of RIG-I in a mouse challenge model of VEEV.

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Report Number
DRDC-SUFFIELD-TM-2008-213 — Technical Memorandum
Date of publication
01 Dec 2008
Number of Pages
26
DSTKIM No
CA032192
CANDIS No
531266
Format(s):
CD ROM

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