Development of LC/MS Methods to be used in Decontamination Research. Part 2. Identification and Quantification of Reaction Products – Final Report

Authors
  1. Noot, D.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN);Vogon Laboratory Services Ltd, Calgary AB (CAN)
Abstract
An analytical method using liquid chromatography-tandem mass spectrometry for the detection of the CWA VX and its reaction products in two decontamination formulations was developed and validated. A list of potential reaction products was obtained from literature. Pure standards of several of these compounds were obtained. Decontamination experiments were performed in order to detect and identify the presence of potential reaction products and determine optimum liquid chromatograph and mass spectrometer settings for their detection. The sampling design for decon experiments was reviewed to ensure accurate results. The final LC-MS/MS method developed is suitable for studies on the agent VX using two decontamination formulations, GD-6 and a novel decon formulation. Generic protocols were prepared for adapting the developed method for use with other agents and decon formulations.

Il y a un résumé en français ici.

Keywords
Chemical warfare agents;Tandem mass spectrometry;VX;LC-MS/MS;Method development;GD-6;F54;Reaction product
Report Number
DRDC-SUFFIELD-CR-2011-112 — Contractor Report
Date of publication
01 May 2011
Number of Pages
94
DSTKIM No
CA035638
CANDIS No
535489
Format(s):
Electronic Document(PDF)

Permanent link

Document 1 of 1

Date modified: