Microarray systems for microbial detection and identification

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Authors
  1. Ford, B.N.
  2. Bader, D.E.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
The relatively recent availability of complete or near-complete sequences of microbial DNA makes it possible to find and exploit unique genetic markers for most microbes. Using microbial genome sequences from public databases, a high-density microarray system has been developed which should enable the identification of hundreds of individual species or strains of pathogenic microorganisms on a single assay platform. This report summarizes the design, development, and testing of this microarray design. The system is currently capable of discriminating multiple human pathogens, Category A biothreats, and some agricultural pathogens, other using supervised analysis methods. Ongoing development will include tools for automation of analysis, and extension of the testing panel of microbes.

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Report Number
DRDC-SUFFIELD-TR-2010-203 — Technical Report
Date of publication
01 Dec 2010
Number of Pages
54
DSTKIM No
CA038135
CANDIS No
538121
Format(s):
Electronic Document(PDF)

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