Secreted Cytokines as Possible Biomarkers of Exposure to Ionizing Radiation

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Authors
  1. Boulay Greene, H.
  2. Daniel, K.
  3. Jones, A.
  4. Prud'homme-Lalonde, L.
Corporate Authors
Defence R&D Canada - Ottawa, Ottawa ONT (CAN)
Abstract
The quest for reliable and unique biomarkers of radiation exposure is an ongoing challenge in the field of radiation biology. Once identified they will provide an invaluable tool for both clinicians wanting to assess therapeutic outcomes of patients as well as first responders and medical personnel needing to rapidly triage populations of potentially exposed people following an radiation/nuclear (RN) event. It has been reported that there is an acute inflammatory response following exposure to ionizing radiation. We hypothesize that this is initiated in part by cytokines secreted from various cell types within the body and that these secreted cytokines may serve as biomarkers for exposure. The various studies described in this report examine the cytokine response following radiation exposure from a single cell line model through to animal studies.

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Report Number
DRDC-OTTAWA-TR-2012-175 — Technical Report
Date of publication
01 Sep 2012
Number of Pages
50
DSTKIM No
CA038445
CANDIS No
538446
Format(s):
Electronic Document(PDF)

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