THE EFFECTS OF NITROUS OXIDE ON P300 AND REACTION TIME

Authors
  1. Fowler, B.
  2. Kelso, B.
  3. Landolt, J.
  4. Porlier, G.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);York Univ, Downsview ONT (CAN) Dept of Physical Education;York Univ, Toronto ONT (CAN) Dept of Psychology
Abstract
The experiment investigated the effects of 3 concentrations (15%, 25% and 35%) of nitrous oxide (N2O) on reaction time (RT) and P300 latency and amplitude. Ten subjects responded to visually presented male or female names in an oddball paradigm with accuracy controlled at a high level. The results were analysed on a single-trial basis. Nitrous oxide increased both RT and P300 latency in a dose-related manner and these variables showed a strong between-dose correlation (r = 0.67). Nitrous oxide also decreased P300 amplitude but only up to the 25% dose. The between-dose correlation for P300 amplitude and RT was negligible (r = -0.14). These results suggest that P300 latency is an index of N2O narcosis and are interpreted as indicating that narcosis involves the slowing of stimulus evaluation processes.
Report Number
DCIEM-87-P-49 — Research Paper; Reprint
Date of publication
01 Jan 1988
Number of Pages
8
Reprinted from
Electroencephalography and Clinical Neurophysiology, no 69, 1988, p 171-178
DSTKIM No
88-01555
CANDIS No
54787
Format(s):
Microfiche filmed at DSIS;Originator's fiche received by DSIS;Hardcopy

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