HISTOPATHOLOGICAL CHANGES IN GASTROCNEMIUS MUSCLES OF RABBITS INJECTED WITH HI-6 IN SALINE
- Authors
- Corporate Authors
- Defence Research Establishment Suffield, Ralston ALTA (CAN)
- Abstract
- The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7. However, histopathological examinations disclosed lesions on some animals but with evidence of healing processes by Day 7; lesions disappeared by Day 14. Further macroscopic and histopathological examinations revealed that lesions associated with the high dose (200 mg/kg) were still prominent on Day 14 but with evidence of healing. Similar lesions seen in muscles injected with saline were significantly less persistent than those associated with HI-6.
- Report Number
- DRES-M-1236 —
- Date of publication
- 15 Feb 1988
- Number of Pages
- 24
- DSTKIM No
- 88-01763
- CANDIS No
- 54994
- Format(s):
- Microfiche filmed at DSIS;Originator's fiche received by DSIS;Hardcopy
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