HISTOPATHOLOGICAL CHANGES IN GASTROCNEMIUS MUSCLES OF RABBITS INJECTED WITH HI-6 IN SALINE

Authors
  1. Connolley-Mendoza, C.E.
  2. Jericho, K.
  3. Bhatti, T.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7. However, histopathological examinations disclosed lesions on some animals but with evidence of healing processes by Day 7; lesions disappeared by Day 14. Further macroscopic and histopathological examinations revealed that lesions associated with the high dose (200 mg/kg) were still prominent on Day 14 but with evidence of healing. Similar lesions seen in muscles injected with saline were significantly less persistent than those associated with HI-6.
Report Number
DRES-M-1236 —
Date of publication
15 Feb 1988
Number of Pages
24
DSTKIM No
88-01763
CANDIS No
54994
Format(s):
Microfiche filmed at DSIS;Originator's fiche received by DSIS;Hardcopy

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