EFFECT OF DIISOPROPYLFLUOROPHOSPHATE ON THE ANTIBODY RESPONSE

Authors
  1. Shek, P.N.
  2. Eastman, T.M.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Clinical Biochemistry
Abstract
The impact of the in-vivo administration of diisopropylfluorophosphate (DFP) on the antibody response in mice was examined. The antigen-specific plaque-forming cell (PFC) response of mice injected with DFP (4mg kg) at the time of immunization with a macrophage-dependent T-cell antigen, trinitrophenylated keyhole limpet hemocyanin (TNP-KLH) or sheep red blood cells (SRBC), was significantly depressed. In contrast, the injection of a similar dose of DFP had no effect on the PFC response of mice immunized with a macrophage-independent B-cell antigen, lipopolysaccharide (LPS). This differential effect suggests a possible detrimental effect of DFP on cells involved in antigen processing and/or presentation which are required for the antibody response to SRBC and TNP-KLH.
Report Number
DCIEM-88-P-01 — Reprint; Research Paper
Date of publication
01 Jan 1988
Number of Pages
6
Reprinted from
Immunopharmacology, no 15, 1988, p 151-156
DSTKIM No
88-03710
CANDIS No
56926
Format(s):
Hardcopy;Originator's fiche received by DSIS

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