PAPER CHROMATOGRAPHY OF SOME AMINE HYDROCHLORIDES AND ACETATES IN ACIDIC SOLVENT SYSTEMS

Authors
  1. Bannard, R.A.B.
  2. Casselman, A.A.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
The chromatography of piperidine, cyclohexylamine, and morpholine hydrochlorides on unwashed Whatman No. 1 and No. 17 papers in t-butanol: acetic acid: water (2:1:1) leads in each case to partial conversion to the acetate salt, the mobility of which differs from that of the hydrochloride. The interconversion is reduced but is not prevented by the use of acid-washed papers and is increased again when the acid-washed papers are treated with sodium, potassium, calcium, or magnesium acetate prior to chromatography. The salt interconversion is continuous during development of the chromatograms, extended development leading to complete disappearance of the hydrochloride. Quantitative chromatography of piperidine and morpholine hydrochlorides revealed that the extent of salt interconversion is ca. 12% on unwashed and calcium ion washed Whatman no. 17 papers, ca. 6% on sodium ion washed papers, and ca. 1% on acid-washed papers. TRUNCATED
Report Number
DCBRL-449 — Reprint; Previously catalogued as DSIS 65-16673
Date of publication
01 Jan 1965
Number of Pages
11
Reprinted from
Canadian Journal of Chemistry, vol 43, 1965, p 395-404
DSTKIM No
89-01250
CANDIS No
59182
Format(s):
Hardcopy;Originator's fiche received by DSIS

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