THE EFFECT OF X-IRRADIATION ON THE METABOLISM OF RIBONUCLEIC ACID IN THE NUCLEI OF THYMOCYTES AND EHRLICH ASCITES CARCINOMA CELLS

Authors
  1. Scaife, J.F.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
Investigations into the metabolism of RNA in irradiated thymocytes, especially with reference to the rapidly labelled RNA II fraction of the nucleolus are reported. Parallel investigations with Ehrlich ascites carcinoma cells have also been carried out to compare a "nonsensitive" cell with the sensitive thymocyte, to determine whether mitotic delay occuring in these cells could be correlated with changes in RNA metabolism. It would appear that the cytological effects produced by 800 rads of X-rays on thymocytes or Ehrlich ascites cells is unlikely to be due to any primary effect upon the biosynthesis of RNA in these cells. By contrast, RNA synthesis appears to be necessary for radiation repair (26).
Report Number
DCBRL-443 — Reprint; Previously catalogued as DSIS 65-02673
Date of publication
01 Jan 1965
Number of Pages
5
Reprinted from
Canadian Journal of Biochemistry, vol 43, 1965, p 119-122
DSTKIM No
89-01253
CANDIS No
59185
Format(s):
Hardcopy;Originator's fiche received by DSIS

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