THE FATE OF DIMETHYL SULFOXIDE APPLIED TO THE SKIN OF THE RAT

Authors
  1. McDermot, H.L.
  2. Finkbeiner, A.J.
  3. Zanette, B.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
Dimethyl sulfoxide (DMSO) applied to the skin of the rat has been shown to be more than 90% absorbed with evaporative losses less than 1%. Following absorption, it was found in the following selected tissues: brain, muscle, kidney, lung, liver, heart, and blood. Peak concentrations in all the tissues were found 1.5 to 2 h after administration of DMSO. The highest concentration was observed in the kidney. Approximately 85% of the applied dose was excreted unchanged in the urine in 24 h.
Report Number
DCBRL-525 — Reprint; Previously catalogued as DSIS 67-09174
Date of publication
01 Jan 1967
Number of Pages
5
Reprinted from
Canadian Journal of Physiology and Pharmacology, vol 45, 1967, p 475-478
DSTKIM No
89-01256
CANDIS No
59188
Format(s):
Hardcopy;Originator's fiche received by DSIS

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