CHROMATOGRAPHIC SEPARATION OF THE 1-ALKOXY-2(3)-HYDROXY-3(2)-AMINOCYCLOHEXANES AND THEIR DERIVATIVES

Authors
  1. Casselman, A.A.
  2. Bannard, R.A.B.
Corporate Authors
Defence Chemical Biological and Radiation Establishment, Ottawa ONT (CAN)
Abstract
Study of the mode of cleavage of the stereoisomeric 1-alkoxy-2,3-epoxycyclohexanes made it necessary to develop methods for the separation and quantitative estimation of the proportions of the positionally isomeric amines (or suitable derivatives) which could result from the action of ammonia on each oxide. To this end, the Paper, thin-layer and vapor phase chromatographic separation of the stereoisomeric 1-alkoxy-2-hydroxy-3-aminocyclohexanes2, their N-acetyl2, O,N-diacetyl2,3 and O,N,N-triacetyl derivatives 3 were examined and the most suitable method was chosen for application to the separation of the position isomers. Results underline the importance of concurrent examination of several chromatographic techniques when difficulty is encountered in the separation of isomers by more conventional means.
Report Number
DCBRE-519 — Reprint; Previously catalogued as DSIS 67-09590
Date of publication
01 Jan 1967
Number of Pages
5
Reprinted from
Journal of Chromatography, vol 28, 1967, p 462-465
DSTKIM No
89-01260
CANDIS No
59192
Format(s):
Hardcopy;Originator's fiche received by DSIS

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