CHANGES IN THE SENSITIVITY OF X-IRRADIATED MICE TO BACTERIAL ENDOTOXIN

Authors
  1. Vittorio, P.V.
  2. Watkins, E.A.
  3. Dziubalo-Blehm, S.
Corporate Authors
Defence Chemical Biological and Radiation Labs, Ottawa ONT (CAN)
Abstract
When endotoxin was injected into mice 4 to 24 hours after X-irradiation the LD sub 50/3 was increased from 500 mu g (non-irradiated control) to 715 mu g and 825 mu g respectively. Adminstration of different doses of X-irradiation showed that increasing the dose from 200 to 600 R caused a linear increase in the endotoxin LD sub 50 of mice and it was in the order of 100 mu g per 200 R. From 800 R to 1400 R there was a decrease in the endotoxin LD sub 50 of mice, but only the 1400-R dose produced a lower LD sub 50 than that in the non-irradiated control. Since whole-body counter studies with 51Cr-labelled endotoxin showed that X-irradiation did not change endotoxin excretion, increased endotoxin LD sub 50 values 4 and 24 hours after X-irradiation were not due to increased rates of endotoxin excretion.
Report Number
DCBRL-524 — Reprint; Previously Catalogued as DSIS 67-08899
Date of publication
01 Jan 1967
Number of Pages
7
Reprinted from
Canadian Journal of Physiology and Pharmacology, vol 45, 1967, p 395-400
DSTKIM No
89-01265
CANDIS No
59197
Format(s):
Hardcopy;Originator's fiche received by DSIS

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