TESTING OF HI-6 AS A THERAPY FOR POISONING BY COMMONLY USED AGRICULTURAL INSECTICIDES

Authors
  1. Schiefer, H.B.
  2. Rousseaux, C.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Saskatchewan Univ, Saskatoon SASK (CAN) Toxicology Research Centre
Abstract
HI-6 is an acetylcholinesterase reactivating compound. Oximes have anticholinergic effects, similar to atropine; can depolarize neuromuscular junctions; may produce a sympathomimetic effect, potentiating the pressor effect of epinephrine; and, paradoxically, may further inhibit acetylcholinesterase when complexed with organophosphates. HI-6 has therapeutic action against potent nerve gas agents such as Soman. Little is known, however, concerning the efficacy of HI-6 against less potent organophosphorus compounds. If this agent is effective in affording protection against accidental exposure to organophosphorus pesticides, it may be possible to broaden the potential use of this compound. The report describes testing of HI-6 as a therapy for poisoning by malathion, parathion, diazinon and carbaryl, commonly used agricultural pesticides.
Report Number
DRES-CR-43/88 — Contract Report
Date of publication
15 Feb 1987
Number of Pages
122
DSTKIM No
89-01326
CANDIS No
59258
Format(s):
Hardcopy;Originator's fiche received by DSIS

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