PROINFLAMMATORY EFFECTS OF LOCAL ABDOMINAL IRRADIATION ON RAT GASTROINTESTINAL TRACT

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Authors
  1. Buell, M.G.
  2. Harding, R.K.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN);Ottawa Univ, Ottawa ONT (CAN) Dept of Physiology
Abstract
Although the role of inflammatory processes in the genesis of late changes in the gastrointestinal tract following exposure to ionizing irradiation has been extensively studied, few studies have concentrated on the presence of an acute inflammatory response in the period immediately following radiation. We therefore examined, in rats, whether the local application of 10 Gy cobalt-60 irradiation to the abdomen led to changes in the gut within the first 24 hr that were consistent with an acute inflammatory response. In stomach, small intestine, and colon, local irradiation led to a significant increase in the accumulation of plasma within the tissue by 4-8 hr following irradiation.
Date of publication
15 Mar 1989
Number of Pages
10
Reprinted from
Digestive Diseases and Sciences, vol 34, no 3, 1989, p 390-399
DSTKIM No
89-02782
CANDIS No
60686
Format(s):
Electronic Document(PDF)

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