IMMUNOLOGIC CONSEQUENCES OF CHRONIC ADMINISTRATION OF PYRIDOSTIGMINE

Authors
  1. Markham, R.J.F.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Atlantic Veterinary Coll, Charlottetown PEI (CAN)
Abstract
The effect of subchronic administration of pyridostigmine on the immune system was evaluated in rats. Three aspects of the immune reactivity and host defence were measured: humoral immunity (antibody or B-lymphocyte-mediated; Jerne plaque assay and antibody accumulation), cell mediated immunity (T-lymphocyte mediated; blastogenesis and delayed skin reaction) and non-specific resistance (macrophage or NK cell activity; chemiluminescence). Pyridostigmine was administered by Alzet osmotic minipump to produce a 45-48% reduction in serum cholinesterase. There were no significant differences in any of the parameters that were measured among the control groups of rats or those treated with pyridostigmine. The measurement of body weights, organ weights, hemoglobin, RBC and WBC numbers as well as WBC differentials confirmed the apparent lack of effect of pyridostigmine on immune responsiveness. TRUNCATED
Report Number
DRES-CR-1/90 — Contract Report (Final)
Date of publication
15 May 1989
Number of Pages
32
DSTKIM No
90-02111
CANDIS No
64376
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: