PLASMA LEVELS OF CUTANEOUS BURN TOXIN AND LIPID PEROXIDES IN THERMAL INJURY

Authors
  1. Sparkes, B.G.
  2. Monge, G.
  3. Marshall, S.L.
  4. Peters, W.J.
  5. Schoenenberger, G.A.
  6. Alloewer, M.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Medical Center Mariastein, Basel (Switzerland);Wellesley Hospital, Toronto ONT (CAN) Ross Tilley Burn Centre;International Society of Surgery, Reinach (Switzerland)
Abstract
Lipid peroxides formed as a consequence of oxygen free radical formation, are responsible for tissue damage in a great variety of pathological conditions including thermal injury. 'Cutaneous burn toxin', formed by application of heat to skin, is thought to be specific to the burn injury. It causes dose-dependent damage to mitochondrial and red cell membranes, and dose-dependent inhibition of interleukin-2-dependent growth of lymphocytes. The possibility that the toxicity of 'cutaneous burn toxin', a lipid-protein, is exerted through lipid peroxides, was examined by measuring the levels of both agents in plasmas of eight burn patients during the first week after their injury. It was observed that plasma lipid peroxides did not appear in parallel with absorption into the circulation of 'cutaneous burn toxin'. Lipid peroxide levels equally common to very low and very high burn toxin levels, were recorded. TRUNCATED
Report Number
DCIEM-89-P-37 — Research Paper; Reprint
Date of publication
15 Oct 1989
Number of Pages
8
Reprinted from
Burns, vol 16, no 2, 1990, p 118-122
DSTKIM No
90-03544
CANDIS No
65793
Format(s):
Hardcopy;Originator's fiche received by DSIS

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