BIOCHEMICAL CHANGES IN RAT LUNG DURING ACUTE PARAQUAT INTOXICATION

Authors
  1. Jurima-Romet, M.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Clinical Biochemistry
Abstract
In male Wistar rats, the 7-day ip LD50 for paraquat was determined to be approximately 38 mg/kg. At a dose of 30 mg/kg, which caused mortality in 14% of the animals, paraquat significantly increased the lung wet weight by 28% and 93% compared to controls at 2 and 3 days after treatment, respectively. The activity of several enzymes present in the lung was affected by paraquat treatment. Pulmonary angiotensin-converting enzyme activity was significantly reduced at 4 hr after paraquat treatment and remained 32-36% below control levels during the following 3-day observation period. Alkaline phosphatase activity in the lung was significantly decreased by 26-33% at 1, 2 and 3 days paraquat treatment. Lung glucose-6-phosphate dehydrogenase activity demonstrated a drop at 4 hr, recovery to control levels at 1 day; and, a subsequent rise to levels 45-55% higher than control at 2 and 3 days. TRUNCATED
Report Number
DCIEM-90-P-24 — Research Paper; Reprint
Date of publication
15 Mar 1990
Number of Pages
10
Reprinted from
Biomedical and Environmental Sciences, vol 3, 1990, p 343-352
DSTKIM No
90-04728
CANDIS No
66960
Format(s):
Hardcopy;Originator's fiche received by DSIS

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