THE EFFECTS OF HIGH PRESSURES OF INERT GASES AND OF ANAESTHETICS ON RAT STRIATAL DOPAMINE IN VITRO

Authors
  1. Paul, M.L.
Corporate Authors
University of Western Ontario, London ONT (CAN) Dept of Pharmacology and Toxicology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Operational deep-sea diving is complicated by two conditions affecting the Central Nervous System. One of these, known as Inert Gas Narcosis (IGN), is due to the presence of nitrogen (N2) in the breathing gas, and presents signs and symptoms of progressive CNS depression similar to anaesthesia as pressure (depth) is increased. Unconsciousness and death may ensue at pressures exceeding 10 Atmospheres Absolute (10 ATA). The other, referred to as the High Pressure Neurological Syndrome (HPNS) was observed when non-narcotic helium (He) wa substituted for N2 to circumvent the problem of IGN. The effects are attributed to pressure per se and include, in man, tremor, EEG changes, and motor incoordination. At higher pressures (80-90 ATA), experimental animals display myoclonus and convulsions, and death occurs at > 200 ATA. The precise neurological changes underlying these two phenomena are unknown.
Date of publication
15 Apr 1989
Number of Pages
266
DSTKIM No
91-02278
CANDIS No
69479
Format(s):
Hardcopy;Originator's fiche received by DSIS

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