LUNG UPTAKE OF LIPOSOME-ENTRAPPED GLUTATHIONE AFTER INTRATRACHEAL ADMINISTRATION

Authors
  1. Jurima-Romet, M.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Health and Welfare Canada, Ottawa ONT (CAN) Health Protection Branch
Abstract
The intratracheal delivery of glutathione (GSH), in liposome-encapsulated form, prolongs retention of the durg in the rat lung. This study has been designed to determine the extent and time-course of pulmonary tissue uptake of administered 14C-labelled liposomes containing (3H)GSH. Liposomes, composed of dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine and distearoylphosphatidylcholine each with or without 30 mol% cholesterol showed a clearance >80% from the bronchoalveolar lavage, 24 h after intratracheal instillation. Lung tissue content of 14C-lipid increased with time: by 72 h, 42-56% of the administered dose was recovered from the tissue. (3H)GSH was present in pulmonary tissue in relatively constant amounts throughout the 72h, ranging from 14-35% of the administered dose. Vesicles composed of DMPC had a low entrapment for GSH. TRUNCATED
Report Number
DCIEM-90-P-22 — Research Paper; Reprint
Date of publication
15 Aug 1990
Number of Pages
5
Reprinted from
J Pharm Pharmacol, vol 43, 1991, p 6-10
DSTKIM No
91-02281
CANDIS No
69482
Format(s):
Hardcopy;Originator's fiche received by DSIS

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