Development of Canadian diagnostic capability for Rift Valley fever virus (RVFV)

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Authors
  1. Weingartl, H.M.
Corporate Authors
Defence Research and Development Canada, Centre for Security Science, Ottawa ON (CAN);Canadian Food Inspection Agency, Winnipeg MB (CAN) National Centre for Foreign Animal Disease
Abstract
CRTI 06-138RD project developed veterinary diagnostic tests for Rift Valley fever virus (RVFV), and identified three species of mosquitoes as potential vectors for RVFV in Canada. RVFV is a zoonotic virus transmitted to people from mosquitoes or ruminants. It is considered a significant biological warfare agent and a severe natural emerging disease threat to Canada, as it has a high potential for rapid spread, endemic establishment, serious economic and public health consequences. Canada had no veterinary diagnostic capability. Ability to rapidly recognize and control by vaccination a RVF outbreak in ruminants is important for protection of people, livestock industry, economy and wildlife. The project has developed diagnostic tests for virus and antibody detection transferrable to low containment and field laboratories. The assays were evaluated on positive samples developed in experimentally infected sheep, goats and calves in a high containment facility at NCFAD. ELISA tests for detection of antibodies were evaluated on negative Canadian field samples from all three species. Viremia model in sheep developed during the project was used in efficacy testing of two vaccine candidates. Canada has now veterinary RVFV diagnostic capability, federal veterinarians trained to recognize RVFV, and veterinary MP12 vaccine (Zoetis) licensed for use in government regulated vaccination program.

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Report Number
DRDC-RDDC2014-C172 — Contract Report
Date of publication
01 Jul 2014
Number of Pages
25
DSTKIM No
CA039650
CANDIS No
800663
Format(s):
Electronic Document(PDF)

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