Association of trauma exposure with proinflammatory activity – A transdiagnostic meta-analysis

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Authors
  1. Tursich, M.
  2. Neufeld, R.W.J.
  3. Frewen, P.A.
  4. Harricharan, S.
  5. Kibler, J.L.
  6. Rhind, S.G.
  7. Lanius, R.A.
Corporate Authors
Defence Research and Development Canada, Toronto Research Centre , Toronto ON (CAN)
Abstract
Exposure to psychological trauma (for example, childhood/early life adversity, exposure to violence or assault, combat exposure, accidents or natural disasters) is known to increase one’s risk of developing certain chronic medical conditions. Clinical and population studies provide evidence of systemic inflammatory activity in trauma survivors with various psychiatric and nonpsychiatric conditions. This transdiagnostic meta-analysis quantitatively integrates the literature on the relationship of inflammatory biomarkers to trauma exposure and related symptomatology. We conducted random effects meta-analyses relating trauma exposure to log-transformed inflammatory biomarker concentrations, using meta-regression models to test the effects of study quality and psychiatric symptomatology on the inflammatory outcomes.
Keywords
stress disorders;traumatic;inflammation;cytokines;c-reactive protein;meta-analysis
Report Number
DRDC-RDDC-2015-P014 — External Literature
Date of publication
01 May 2015
Number of Pages
9
DSTKIM No
CA040488
CANDIS No
801685
Format(s):
Electronic Document(PDF)

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