Investigating cellular reprogramming as a tool for identifying neural based assays for post-traumatic stress disorder (PTSD) – Cellular reprogramming for PTSD

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Authors
  1. Ellis, J.
Corporate Authors
Defence Research and Development Canada, Toronto Research Centre , Toronto ON (CAN);Hospital for Sick Children, Toronto ONT (CAN)
Abstract
Post-traumatic stress disorder (PTSD) is a stress-related disorder that develops after exposure to intense trauma. Over half of the population will be exposed to a psychologically traumatic event at some point in their life, with approximately 10-20% moving on to develop PTSD1. Accumulating evidence indicates that the alteration of proper neuronal structure and function in the cortex via altered gene expression underlies the pathophysiology of PTSD2-5. However, the lack of appropriate animal model systems and/or the difficulty of obtaining human brain tissue have been a major hurdle to evaluating and interpreting these findings.
Keywords
stem cells;cellular reprogramming;neurons;neuropsychiatric disorders
Report Number
DRDC-RDDC-2015-C095 — Contract Report
Date of publication
01 Mar 2015
Number of Pages
20
DSTKIM No
CA040847
CANDIS No
801912
Format(s):
Electronic Document(PDF)

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