Nucleic Acid-based Drugs against Emerging Zoonotic Viruses

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Authors
  1. Wong, J.P.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
Global outbreaks of diseases by zoonotic viruses have steadily increased in recent years. These emerging viruses are hard to protect against due to lack of approved antiviral drugs and vaccines against them. The aim of this review is to discuss how advances in genomics, rational drug design and innate immune signaling can contribute to the design of nucleic acid-based drugs which can play a significant role in combating these emerging threats. Specifically, siRNAs, antisense oligonucleotides and microRNAs have specific antiviral activity mediated by gene-silencing, and toll-like receptor agonists eliciting broad-spectrum innate and antiviral immune responses. This review will discuss the state of development, safety and efficacy of preclinical and/or clinical studies, and outline next steps necessary to full licensure.
Keywords
pandemic influenza;antiviral drugs;experimental;cytokine storm
Report Number
DRDC-RDDC-2015-P051 — External Literature
Date of publication
01 Aug 2015
Number of Pages
19
DSTKIM No
CA040853
CANDIS No
801919
Format(s):
Electronic Document(PDF)

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