Biomarkers of Injury and Infection

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Authors
  1. Sensen, C.W.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN);Calgary Univ, Calgary Alta (CAN) Dept of Biochemistry and Molecular Biology
Abstract
Sepsis is an important cause of morbidity and mortality in post-surgery, and in the case of infection with bio-threat agents. Sepsis can be defined as Systemic Inflammatory Response Syndrome (SIRS), in combination with verified microbiological infection, as determined by positive microbial culture from blood. When symptoms of SIRS are observed (fever (or low body temperature), elevated heart rate, elevated breathing rate, falling white cell count), sequelae of the infection may already be present. Serious effects include hypotension, multiple organ dysfunction, coagulopathy, renal failure, CNS dysfunction, and gastrointestinal bleeding. Such patients are extremely ill. The earlier a clear diagnosis can be made, the sooner life saving treatment can be initiated. Conversely, In collaboration with Dstl Porton Down, (U.K.), DRDC Suffield has been involved in searching for pre-symptomatic host biomarkers of sepsis, with a view to identifying sepsis cases early, so that pre-emptive treatment can occur. Dstl has embarked on a multi-year multi-center recruitment of health pre-surgical patients, with a view to capturing some of the sepsis cases which will arise in post-surgical recovery. Patients are recruited as healthy elective surgery cases, and blood samples collected daily until the patient is discharged healthy, or diagnosed with sepsis.
Keywords
sepsis;infection;nucleic acid;DNA
Report Number
DRDC-RDDC-2015-C245 — Contract Report
Date of publication
01 Mar 2015
Number of Pages
38
DSTKIM No
CA041599
CANDIS No
802849
Format(s):
Electronic Document(PDF)

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