Virulence determinants of New World alphaviruses and broad-acting therapeutic strategies

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Authors
  1. Wu, J.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
New World alphaviruses of eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV) and Venezuelan equine encephalitis virus (VEEV) are endemic in North and South America, and infect humans and equine through mosquitoes. In addition, these viruses are highly infectious when aerosolized, making them potential biowarfare and bioterrorism agents. Currently, no approved vaccines or drugs are available for prevention and treatment. Extensive studies have been carried out to understand molecular mechanisms for virulence among New World alphaviruses. This review will focus on virus-encoded, interferon antagonizing proteins which play major role in determination of virulence of New World alphaviruses.
Keywords
new world alphaviruses;eastern equine encephalitis virus;western equine encephalitis virus;Venezuelan equine encephaltis virus;virulent determinants;structural proteins;interferon;broad-acting antivirals
Report Number
DRDC-RDDC-2016-P007 — External Literature
Date of publication
01 Dec 2015
Number of Pages
11
DSTKIM No
CA041916
CANDIS No
803072
Format(s):
Electronic Document(PDF)

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