Bisphosphocins – Novel antimicrobials for enhanced killing of drug-resistant and biofilm-forming bacteria

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Authors
  1. Wong, J.
  2. DiTullio, P.
  3. Parkinson, S.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
The global prevalence of antibiotic resistance and the threat posed by drug-resistant superbugs are a leading challenge confronting modern medicine in the 21st century. However, the progress on the development of novel antibiotics to combat this problem is severely lagging. A more concerted effort to develop novel therapeutic agents with robust activity and unique mechanisms of action will be needed to overcome the problem of drug resistance. Furthermore,biofilm forming bacteria are known to be increasingly resistant to the actions of antibiotics and are a leading cause of mortality or morbidity in nosocomial infections. Bisphosphocins (also scientifically known as nubiotics) are novel small protonated deoxynucleotide molecules,and exert their antibacterial activity by depolarization of the bacterial cell membraneçausing bacterial cell death. Bisphosphocins may represent an effective weapon against antibiotic-resistant and biofilm-forming pathogenic bacteria. Preclinical efficacy studies in animals have shown that the compounds are safe and, efficacious against various bacterial infections, including drug-resistant pathogens. In vitro biochemical analysis confirmed that the bactericidal activity of bisphosphocins is mediated by depolarization of the bacterial cell membrane,and these compounds are better able to penetrate through bacterial biofilm and kill the biofilm encased bacteria. This article will cover the structure,mode of action, safety,efficacy and the current state
Keywords
antibiotic resistance;biofilm;bisphosphocins;broad spectrum;membrane depolarization;treatment
Report Number
DRDC-RDDC-2016-P011 — External Literature
Date of publication
22 Jan 2016
Number of Pages
8
DSTKIM No
CA041930
CANDIS No
803089
Format(s):
Electronic Document(PDF)

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