Evaluation of dispersive ultrasound for diagnosis of blast-induced traumatic brain injury in rodents

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Authors
  1. Burrell, C.
  2. Tenn, C.
  3. Shek, P.
  4. Caddy, N.
  5. Garrett, M.
  6. Shei, Y.
Corporate Authors
Defence Research and Development Canada, Toronto Research Centre , Toronto ON (CAN);Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
Ultrasonic frequency dispersion was used to study primary blast-induced mild traumatic brain injuries in rats. Transcranial ultrasonic pulses were transmitted noninvasively and the frequency-dependent variations in propagation speed were measured in controls and shockwave-exposed animals. Rats were exposed to a single shockwave at a pressure of 0, 141 or 223 kPa, shockwave intensities known to induce functional deficits and neuroinflammatory response in the same animal model. Following exposure, data was collected at 24, 48 and 72 hours. A two-class Support Vector Machine diagnostic classifier was applied to distinguish between controls and shockwave-exposed animals. The classifier could not reliably distinguish between these groups at the incident peak pressures and post-exposure intervals used in this study.

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Keywords
ultrasound;frequency dispersion;medical diagnostics;neurological injury;blast exposure;tissue characterization;machine learning;support vector machine;blast injury;traumatic brain injury;animal study
Report Number
DRDC-RDDC-2016-R065 — Scientific Report
Date of publication
01 May 2016
Number of Pages
60
DSTKIM No
CA042626
CANDIS No
803773
Format(s):
Electronic Document(PDF)

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