Rational design of therapies for medical and casualty management of botulinum toxin poisoning

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Authors
  1. Simpson, L.L.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN);Thomas Jefferson University, Philadelphia PA (US)
Abstract
The work conducted under this contract focused on therapeutic antibodies. The research was conducted in two phases: 1) determine the mechanisms that underlie inhalation poisoning by botulinum toxin, then use inhalation poisoning as a model for a bioweapons event, and 2) determine the mechanisms that underlie the ability of therapeutic antibodies to provide post-challenge protection against inhalation botulism. The work revealed that there are three layers of protection afforded by antibodies: 1) blockade of absorption at mucosal surfaces, 2) evoked clearance that leads to antibody-toxin complexes accumulating in the liver, and 3) blockade of toxin binding at target organs.

Il y a un résumé en français ici.

Keywords
casualty management;botulinum;toxins;poisons
Report Number
DRDC-SUFFIELD-CR-2012-081 — Contract Report
Date of publication
01 Feb 2012
Number of Pages
64
DSTKIM No
CA042848
CANDIS No
804743
Format(s):
Electronic Document(PDF)

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