Altered systemic inflammatory profiles in athletes with a history of concussion

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Authors
  1. Di Battista, A.P.
  2. Rhind, S.G.
  3. Richards, D.
  4. Baker, A.J.
  5. Hutchison, M.
Corporate Authors
Defence Research and Development Canada, Toronto Research Centre , Toronto ON (CAN)
Abstract
Importance: The long-term health effects of concussion are unknown. Inflammation is pivotal to secondary injury processes and the etiology of neurodegenerative diseases. We characterized circulating inflammatory mediators in healthy male and female athletes with and without a history of concussion. Methods: Blood samples from 53 healthy athletes (males, n = 29; females, n = 24) with (n = 28) and without (n = 25) previous concussion history were assessed for 29 inflammatory markers and 4 neuroinjury markers by immunoassay. Results: Numerous chemokine concentrations were elevated in athletes with a history of concussion versus no history of concussion: monocyte chemoattractant protein (MCP)-4 (p = 0.003); thymus- and activation-regulated chemokine (p = 0.001); interferon gamma induced protein -10 (p < 0.001), interleukin-8 (p = 0.019), MCP-1 (p = 0.006), macrophage-derived chemokine (p = 0.039), and macrophage inflammatory protein (MIP)-1 (p < 0.05). Brain derived neurotrophic factor (BDNF) was also elevated (p = 0.016). A positive correlation was found between number of previous concussions and both TARC (r = 0.45, p = 0.001) and IP-10 (R = 0.44, p = 0.001). An inverse correlation was found between days from the last concussion and both IP-10 (r = -0.45, p = 0.041) and MIP-1 (r = -0.49, p = 0.020). Interpretation: Athletes with concussion history displayed elevated systemic chemokine concentrations versus athletes without concussion history. Chemokines were ass
Keywords
concussion;inflammation;biomarkers
Report Number
DRDC-RDDC-2016-P140 — External Literature
Date of publication
20 Dec 2016
Number of Pages
28
DSTKIM No
CA042887
CANDIS No
804783
Format(s):
Electronic Document(PDF)

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