A histopathologic evaluation of pig skin following exposure to sulphur mustard and lewisite

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Authors
  1. Nation, P.N.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN);Veterinary Pathology Lab, Edmonton Alta (CAN)
Abstract
Microscopic examination was conducted on a series of skin samples from domestic pigs after cutaneous exposure to mustard gas for periods of 4, 8, 12, and 16 minutes followed by either warming or cooling. Samples were collected 7 days post exposure. It was found that a period of cooling following mustard gas exposure delayed the onset of epithelial damage, and that period of warming resulted in a tendency for damage to become apparent with shorter exposure times. Under the conditions of this study, increasing the length of the period of post exposure cooling did not appear to proportionally increase the exposure time needed to eventually cause damage, i.e., it appeared that the effect of cooling was not dose dependent.

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Keywords
Chemical warfare;Chemical warfare agents;Sulfur mustard;Mustard gas;Lewisite;Vesicants;Pathology;Histopathology;Skin
Report Number
DRDC-SUFFIELD-CR-2002-152 — Contract Report
Date of publication
01 Feb 2002
Number of Pages
196
DSTKIM No
CA044615
CANDIS No
804938
Format(s):
Electronic Document(PDF)

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