A histopathologic evaluation of guinea pig skin following exposure to sulphur mustard and lewisite with cooling

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Authors
  1. Nation, P.N.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN);Veterinary Pathology Lab, Edmonton Alta (CAN)
Abstract
Microscopic examination was conducted on a series of skin samples from hairless guinea pigs after topical to mustard gas. In one series of exposures, skin was exposed for 2, 4, or 6 minutes, followed by maintenance for 7, 24, or 72 hours or 7 days at either room temperature or a 5°C. In a second series the skin was either cooled or left uncooled for 6 hours prior to euthansia of the animals and harvesting of skin samples. It was concluded that under the experimental conditions of this study: 1) Lewisite caused more severe microscopic lesions than sulphur mustard 2) That increased time of exposure to sulphur mustard resulted in increasing severity of microscopic lesions 3) That maximum microscopic anatomic damage was evident at 72 hours after exposure 4) That microscopic lesions were resolving by 7 days post-exposure, and 5) That skin exposed to ambient temperatures of 5° exhibited less severe damage than skin exposed to room temperature at 72 hours and 7 days post exposure.

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Keywords
Chemical warfare;Chemical warfare agents;Sulfur mustard;Mustard gas;Lewisite;Vesicants;Pathology;Histopathology;Skin
Report Number
DRDC-SUFFIELD-CR-2002-153 — Contract Report
Date of publication
01 Feb 2002
Number of Pages
118
DSTKIM No
CA044616
CANDIS No
804939
Format(s):
Electronic Document(PDF)

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