Identification of the 6K-E1 protein of western equine encephalitis virus as a vaccine target

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Authors
  1. Wu, J.Q.H.
  2. Barabé, N.D.
  3. Swayze, R.D.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
Vaccination is a cost-effective medical countermeasure against the threat of viral biological agents and endemic viral diseases. Currently, the number of effective vaccines available for the Canadian Foreces (CF) is limited. We have been focusing on the identification of the vaccine targets for western equine encephalitis virus (WEEV), which belongs to the alphaviral agents which also include Venezuelan equine encephalitis virus and eastern equine encephalitis virus. We previously found that the envelope proteins of WEEV elicit rapid immune protection against the lethal challenge of the virus. In this study, we further defined that the 6K-E1 envelope protein of WEEV is a major target for vaccine development. This finding will aid the design of an improved vaccine for WEEV and other alphaviruses.

Il y a un résumé en français ici.

Keywords
vaccine;western equine encephalitis virus;envelope protein
Report Number
DRDC-SUFFIELD-TM-2009-201 — Technical Memorandum
Date of publication
01 Nov 2009
Number of Pages
32
DSTKIM No
CA044527
CANDIS No
805072
Format(s):
Electronic Document(PDF)

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