Developing Mesenchymal Stem Cell-Based Therapy for Severe Skin Burn Wounds

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Authors
  1. Hu, W-G.
  2. Braid, L.R.
  3. Nagata, L.P.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
One of the most common battlefield afflictions is severe skin injury, including burn trauma. Although medical strategies have been developed to improve burn wound healing, current approaches still fall short of restoring normal appearance and function in the case of third-degree (full-thickness) wounds. In the normal healing process, skin wounds do not regenerate the damaged tissue, but rather replace it with scar tissue which lacks normal function and appendages such as hair follicles and subcutaneous glands. The formation of fibrotic scars after wounding poses a major medical problem and expense. Skin scarring and appendage deficiency, following wound healing, often result in loss of skin function, restriction of mobility leading to disability, and adverse psychological effects, all of which severely affect the quality of life for patients. Application of mesenchymal stem cells (MSCs) to excision and burn wounds has been shown to improve the rate and integrity of the natural healing process. Mounting evidence suggests that transplanted MSCs recruit endogenous stem cells to the site of injury and attenuate the inflammatory response of the host through a paracrine (localized) response. Importantly, human MSCs are immune-privileged, and thus can be transplanted between individuals without rejection. However, current MSC-based therapies do not produce seamless skin regeneration, suggesting that the innate ability of MSCs to improve wound healing is limited. The ability of thera
Keywords
skin injury;burn injury;healing;stem cells;mesenchymal stem cells;gene therapy;genetic engineering
Report Number
DRDC-SUFFIELD-TM-2012-028 — Technical Memorandum
Date of publication
01 Apr 2012
Number of Pages
46
DSTKIM No
CA046016
CANDIS No
806487
Format(s):
Electronic Document(PDF)

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