Chemical Weapon Agent Studies in Domestic Swine – Part 5: Comparative Bioavailability of Different HI-6 Salt Forms in the Domestic Pig

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Authors
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN);Kinchyle Enterprises Inc, Medicine Hat ALTA (CAN)
Abstract
A well-developed anesthetized domestic swine model has been utilized to study the following effect of chemical weapons (CW): 01 – Comparative bioavailability of different HI-6 salt forms in the domestic pig. The bioavailability of the dihydrochloride salt of HI-6a (currently utilized) was compared to that of the dimethanesulfonate salt (HI-6b). The latter is more water-soluble at low temperatures. The salts appear similarly clinically, biochemically or hematologically in the “equivalent” doses administered (HI-6 dihychloride = 500 mg, HI-6 dimethanefulfonate = 633 mg.) A notable exception might be the observation that the combination of pyridostigme (PYR)/HI-6b increases airway resistance. Timed plasma and urine samples were collected for HPLC analysis.

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Keywords
chemical weapons
Report Number
DRDC-SUFFIELD-CR-2002-170 — Contract Report
Date of publication
01 Sep 2002
Number of Pages
46
DSTKIM No
CA046026
CANDIS No
806497
Format(s):
Electronic Document(PDF)

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