Blood biomarkers are associated with brain function and blood flow following sport concussion


  1. DiBattista, A.
  2. Churchill, N.
  3. Schweizer, T.A.
  4. Rhind, S.G.
  5. Richards, D.
  6. Baker, A.J.
  7. Hutchinson, M.G.
Corporate Authors
Defence Research and Development Canada, Toronto Research Centre , Toronto ON (CAN);Toronto Univ, Toronto Ont (CAN) Faculty of Kinesiology and Physical Education;ST MICHAEL'S HOSPITAL, TORONTO ONT (CAN)
Background: Secondary injury pathophysiology after sport-related concussion (SRC) is poorly understood. Blood biomarkers may be a useful tool for characterizing these processes, yet there are limitations in their application as a single modality. Combining blood biomarker analysis with advanced neuroimaging may help validate their continued utility in brain injury research by elucidating important secondary injury mechanisms. Hence, the purpose of this study was to evaluate co-modulation between peripheral blood biomarkers and advanced functional brain imaging after SRC. Methods: Forty-three university level athletes from 7 sports were recruited (16 recently concussed athletes; 15 healthy athletes with no prior history of concussion; 12 helathy athletes with a history of concussion). Seven blood biomarkers were evaluated: s100B, total tau (T-tau), von Willebrand factor (vWF), brain derviced neurotrophic factor (BDNF), peroxiredoxin (PRDX)-6, monocyte chemoattractant protein (MCP)-1 and -4. Restingstate functional MRI was employed to assess global neural conectivity (Gconn), and arterial spin labelling was used to evaluate cerebral blood flow (CBF). We tested for concurrent alterations in blood biomarkers and MRI measures of brain function between athlete groups using a non-parametic, bootstrapped resampling framework. Results: Compared to healthy athelets, recently concussed athletes showed greater concurrent alterations in several peripheral blood biomarker and MRI measures:
brain injury;concussion;biomarker;s100B;GFAP;T-Tau;PRDX-6;MCP-1;MCP-4;athletes
Report Number
DRDC-RDDC-2018-P085 — External Literature (P)
Date of publication
01 Mar 2018
Number of Pages
Reprinted from
Journal of Neuroimmunology Volume 319, 19 March 2018, Pages 1 8
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