Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis

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Authors
  1. Stratilo, C.W.
  2. Swayze, R.
  3. Jager, S.
Corporate Authors
Defence Research and Development Canada, Suffield Research Centre, Ralston AB (CAN)
Abstract
Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate.

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Keywords
Burkholderia pseudomallei;Burkholderia mallei;Hemagglutinin-like protein;Recombinant vaccine antigen
Report Number
DRDC-RDDC-2018-R189 — Scientific Report
Date of publication
01 Oct 2018
Number of Pages
25
DSTKIM No
CA047702
CANDIS No
808083
Format(s):
Electronic Document(PDF)

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