CYCLIC GMP LEVELS IN CEREBELLUM FOLLOWING GD ADMINISTRATION

Authors
  1. Lundy, P.M.
  2. Magor, G.F.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Rats treated with GD (soman) and sacrificed at the onset of convulsions had cerebellar cyclic guanosine 3'5' monophosphate (cCMP) levels 97% above control levels. Diazepam and clonazepam have been shown to be effective in treating animals poisoned with GD. Low doses of diazepam and clonazepam and high doses of aminooxyacetic acid, which interfere with GABA metabolism, blocked the convulsions and the increase in cGMP levels in the cerebellum induced by GD. High doses of atropine failed to alter cGMP levels, alter convulsions noticeably or block the soman induced increase in cGMP levels.
Report Number
TP-484 —
Date of publication
15 Dec 1977
Number of Pages
9
DSTKIM No
78-00522
CANDIS No
81241
Format(s):
Hardcopy;Originator's fiche received by DSIS

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