THE GANGLIONIC BLOCKING PROPERTIES OF THE CHOLINESTERASE REACTIVATOR HS-6

Authors
  1. Lundy, P.M.
  2. McKay, D.H.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Following i.v. administration of 30 mg/kg of the cholinesterase reactivator HS-6, blood pressure fell (up to 50 mm/Hg) and maximal blood levels of HS-6 reached 242 mu g/ml. HS-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation. Doses of HS-6 below those tested therapeutically against soman in different animal species (3.59-10.77mg/kg) progressively blocked the ganglion stimulating effects of nicotine and dimethylphenylpiperazinium but not those following adrenaline, a pattern similar to that produced by hexamethonium but only 1/84 as potent. HS-6, like hexamethonium and mecamylamine, progressively blocked the contraction of the nictitating membrane of the cat resulting from pre-ganglionic stimulation.
Report Number
TP-480 —
Date of publication
15 Jan 1978
Number of Pages
20
DSTKIM No
78-00640
CANDIS No
81358
Format(s):
Hardcopy;Originator's fiche received by DSIS

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