EFFICACY OF PRO-PAM (N-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME HYDROCHLORIDE) AS A TREATMENT FOR ORGANOPHOSPHATE POISONING

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Pro-PAM (N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) was compared to pyridine-2-aldoxime chloride (PAM) as a treatment for organosphosphate poisoning. Pro-PAm was generally less toxic than PAM in mice and pH of the vehicle did not appear to alter the toxicity of Pro-PAM. Pro-PAM alone and combined with atropine improved the protective ratio (PR) of DFP and sarin in mice, whereas it improved very slightly the PR of soman in guinea pigs. The PR obtained with Pro-PAM combined with carbamate prophylaxis and atropine therapy versus soman poisoning was inferior to that obtained with PAM. In most cases Pro-PAM and atropine prophylaxis produced higher brain acetylcholinesterase (AChE) levels than PAM and atropine. Pro-PAM was not a significant improvement in the therapy of organophosphorus poisoning. Tests done with mice and guinea pigs.
Report Number
TP-487 —
Date of publication
15 Feb 1978
Number of Pages
20
DSTKIM No
78-00849
CANDIS No
81565
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: