EFFECT OF FLURAZEPAM UPON GD-INDUCED SEIZURE ACTIVITY AND CONVULSIONS

Authors
  1. Lipp, J.A.
  2. Linderman, T.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys with chronic, implanted recording electrodes were exposed to GD (7-10 micro g/kg) and given flurazepam (2-4 mg/kg) by IV injection. Flurazepam was administered after the onset of seizure activity and convulsions. Flurazepam was able to reduce, but not suppress, the abnormal EEG activity in 4 monkeys, while in two others it did not alter the activity. In two animals, the activity only persisted for a short period of time and the record became isoelectric due to respiratory depression. Atropine was administered at the onset of apnea. The results of the study suggest that flurazepam does not have the anticonvulsant properties that have been exhibited by either clonazepam or diazepam in the treatment of GD poisoning.
Report Number
TP-475 —
Date of publication
15 Mar 1978
Number of Pages
11
DSTKIM No
78-01366
CANDIS No
82072
Format(s):
Hardcopy;Originator's fiche received by DSIS

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