GAMMA AMINOBUTYRIC ACID METABOLISM IN DIFFERENT AREAS OF RAT BRAIN AT THE ONSET OF GD-INDUCED CONVULSIONS

Authors
  1. Lundy, P.M.
  2. Magor, G.
  3. Shaw, R.K.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
In experiments aimed at examining the mechanism of nerve gas induced convulsions and their treatment, groups of 10 animals were injected with 1LD sub 50 GD alone or GD preceded by the anticonvulsants diazepam, aminooxyacetic acid (AOAA) or n-dipropyl-acetic acid (nDPA) and the severity of convulsions was rated. At appropriate doses diazepam, AOAA and nDPA greatly reduced GD convulsions. Glutamic acid decarboxylase (GAD) and gamma aminobutyric acid transaminase (GABA-T) activities in different brain areas were unaffected by GD in animals sacrificed at the onset of convulsions. GD also did not change the brain GABA levels. Diazepam and AOAA both abolished convulsions while diazepam had no effect on either of the measured parameters of GABA metabolism (GABA-T activity nor GABA levels). AOAA, on the other hand, inhibited GABA-T and raised GABA levels significantly.
Report Number
TP-485 —
Date of publication
15 Mar 1978
Number of Pages
16
DSTKIM No
78-01592
CANDIS No
82291
Format(s):
Hardcopy;Originator's fiche received by DSIS

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