EFFECT OF ATROPINE UPON THE CEREBROVASCULAR SYSTEM DURING GD-INDUCED RESPIRATORY DEPRESSION

Authors
  1. Lipp, J.A.
  2. Dola, T.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The effect of GD-induced respiratory depression upon cerebral vascular physiology was studied in monkeys. There was a significant decrease in heart rate, mean arterial blood pressure, cerebral blood flow and cerebral perfusion pressure during the onset of respiratory depression, which terminated as apnea. Administration of atropine resulted in an immediate increase in all of the above mentioned parameters which coincided with improvement in respiration. It was concluded that GD impaired cerebral autoregulation, which resulted in a decrease in cerebral blood flow and cerebral perfusion pressure. It was suggested that respiratory depression resulted, in part, from anoxia. Administration of atropine increased the cerebral blood flow and cerebral perfusion pressure, which, in turn, possibly reversed the anoxic conditions resulting in the improvement of respiration.
Report Number
TP-488 —
Date of publication
15 Mar 1978
Number of Pages
12
DSTKIM No
78-01593
CANDIS No
82292
Format(s):
Hardcopy;Originator's fiche received by DSIS

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