MECHANISM OF THE CARDIOVASCULAR ACTIVITY OF DIBENZOXAZEPINE IN CATS

Authors
  1. Lundy, P.M.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Small i.v. doses of dibenzoxazepine (DBO) (50-400 mu/kg) given to anesthetized cats resulted in dose related increases in heart rate (up to 70 beats/min) and blood pressure (up to 80 mm Hg). The pressor response was blocked by pretreatment of the animals with phentolamine pretreatment for 3 days with 6-hydroxdopamine; with mecamylamine and spinal transection between C sub 1 and C sub 2 but not by propranolol or adrenalectomy. The increase in heart rate was blocked by pretreatment with propranolol, 6-hydroxydopamine, mecamylamine and spinal transection whereas adrenalectomy only affected the response slightly. DBO produced only negative effects on the isolated rabbit heart. Bioassay of arterial blood showed an increased level of circulating catecholamines corresponding to the cardiovascular stimulation. DBO had no tyramine-like activity on the isolated rabbit aortic strip but slightly potentiated the contraction induced by noradrenaline. TRUNCATED
Date of publication
01 Jan 1978
Number of Pages
9
Reprinted from
Reprinted from:European J of Pharmacology, vol 48, 1978, p 271-279
DSTKIM No
78-02923
CANDIS No
83607
Format(s):
Hardcopy;Originator's fiche received by DSIS

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