EFFECT OF A WATER-SOLUBLE BENZODIAZEPINE, RD 21-3981 UPON GD-INDUCED SEIZURE ACTIVITY AND CONVULSIONS IN THE MONKEY
- Authors
- Corporate Authors
- Defence Research Establishment Suffield, Ralston ALTA (CAN)
- Abstract
- Monkeys with chronic implanted cerebral electrodes were exposed to the cholinesterase inhibitor GD. At the onset of the GD-induced seizure activity and convulsions, the water-soluble benzodiazepine derivative RO 21-3981 and atropine were administered by intravenous injection. There was an immediate suppression of the high voltage sharp wave and spike activity which was replaced by a high voltage, multiple sharp wave activity and all convulsive activity ceased. The animals appeared unresponsive. The bradycardia and dyspnea associated with GD-poisoning were reversed by the action of the atropine. All animals remained very sedate for 1 - 1 1/2 hours and were ataxic during the recovery period.
- Report Number
- TP-498 —
- Date of publication
- 15 May 1979
- Number of Pages
- 12
- DSTKIM No
- 79-01950
- CANDIS No
- 86300
- Format(s):
- Originator's fiche received by DSIS;Hardcopy
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