EFFECT OF A WATER-SOLUBLE BENZODIAZEPINE, RD 21-3981 UPON GD-INDUCED SEIZURE ACTIVITY AND CONVULSIONS IN THE MONKEY

Authors
  1. Lipp, J.A.
  2. Dola, T.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys with chronic implanted cerebral electrodes were exposed to the cholinesterase inhibitor GD. At the onset of the GD-induced seizure activity and convulsions, the water-soluble benzodiazepine derivative RO 21-3981 and atropine were administered by intravenous injection. There was an immediate suppression of the high voltage sharp wave and spike activity which was replaced by a high voltage, multiple sharp wave activity and all convulsive activity ceased. The animals appeared unresponsive. The bradycardia and dyspnea associated with GD-poisoning were reversed by the action of the atropine. All animals remained very sedate for 1 - 1 1/2 hours and were ataxic during the recovery period.
Report Number
TP-498 —
Date of publication
15 May 1979
Number of Pages
12
DSTKIM No
79-01950
CANDIS No
86300
Format(s):
Originator's fiche received by DSIS;Hardcopy

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