NEISSERIA MENINGITIDIS INFECTION IN MICE: INFLUENCE OF IRON, VARIATIONS IN VIRULENCE AMONG STRAINS, AND PATHOLOGY

Authors
  1. Holbein, B.E.
  2. Jericho, W.F.
  3. Likes, G.C.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The influence of iron on Neisseria meningitidis infection in C-57 mice was examined. Iron sulfate, ferric ammonium citrate, and iron sorbitol citrate all proved to be too toxic for use as infection-enhancing agents. Iron dextran displayed an extremely low toxicity, enhanced infection in a dose-dependent manner, and resulted in infection enhancement factors approaching E9 for virulent strains of N. meningitidis. Fatal iron dextran-enhanced infection was shown to be reversible by in vivo chelation of iron. Virulent strains of N. meningitidis produced symptoms of infection and pathological lesions in mice both with and without iron pretreatment, but an avirulent strain failed to produce symptoms of infection or pathological lesions, regardless of iron administration. Iron dextran-enhanced infection in mice proved to be a useful model for the examination of virulence of various N. meningitidis strains. TRUNCATED
Date of publication
01 Jan 1979
Number of Pages
7
Reprinted from
Infection and Immunity, vol 24, no 2, 1979, p 545-551
DSTKIM No
79-02949
CANDIS No
87278
Format(s):
Originator's fiche received by DSIS;Hardcopy

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