GANGLION BLOCKING PROPERTIES OF SOME BISPYRIDINIUM SOMAN ANTAGONISTS

Authors
  1. Lundy, P.M.
  2. Tremblay, K.P.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Various doses of several bispyridinium compounds (HS-6, HI-6, HGG-42 and SAD-128) known to protect animals against the irreversible cholinesterase inhibitor soman were examined to determine their effects on the cardiovascular and respiratory system of cats. Although the potency varied considerably all of the compounds tested lowered the blood pressure, which appeared to be the result of ganglion blocking properties as determined by their reduction of the pressor response to dimethylphenylpiperazinium and the blockade of the contraction of the preganglionically stimulated cat nictitating membrane. Some of the compounds caused cessation of respiration at much lower doses than others but did so at doses greater than those causing ganglion blockade.
Date of publication
01 Jan 1979
Number of Pages
7
Reprinted from
J of Pharmacology, vol 60, 1979, p 47-58
DSTKIM No
80-00605
CANDIS No
88307
Format(s):
Hardcopy;Originator's fiche received by DSIS

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