INVESTIGATIONS INTO THE MECHANISM OF MORPHINE AND ETHANOL INHIBITION IN THE GUINEA PIG ILEUM LONGITUDINAL MUSCLE STRIP

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
It has been noted that the analgesic property of ethanol bears a marked resemblance to that of morphine. The purpose of the study was to determine if the mechanism of action of morphine and ethanol was similar using the guinea pig ileal longitudinal muscle strip (GPI-LMS). Ethanol (35-260mM) depressed the twitch response and the acetylcholine- (ACh-), KCl-, and BaCl2-induced contractions to the same extent while having no significant effect on the binding of (super 3 H)quinuclidinyl benzilate ((super 3 H)QNB) to muscarinic receptors. Morphine (53-530nM) inhibited the twitch response and to a lesser extent BaCl2- and KCl-induced contractions while having no significant effect on either ACh-induced contractions or the binding of (super 3 H)QNB to muscarinic receptors. Naloxone and increased (Ca super 2+) reversed the inhibitory effects of morphine but not ethanol. TRUNCATED
Report Number
TP-501 —
Date of publication
01 Jan 1980
Number of Pages
6
Reprinted from
Can J Physiol Pharmacol, vol 58, no 3, 1980, p 265-270
DSTKIM No
80-02589
CANDIS No
90272
Format(s):
Hardcopy;Originator's fiche received by DSIS

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